LUBI seminar series: “Single cell RNA sequencing: Beyond gene expression”. Yogita Sharma, LU
Yogita Sharma works as a joint bioinformatician for Molecular neurogenetics and Developmental and Regenerative Neurobiology labs in MultiPark. Yogita holds a PhD in computational biology from University of Bergen, Norway. She is interested in understanding human brain development and diseases using single cell multi-omics approaches.
Single cell RNA sequencing has emerged as a powerful technology in providing important molecular insights into the complexity of human brain and diseases. However, most of the times the analysis has been limited to protein-coding gene expression. Here we present a case study where single cell RNA sequencing dataset was used to analyze transposable elements (TEs) expression. TEs are mobile genetic elements that make up at least 50 percent of our genome. These elements are transcriptionally silenced in adult tissues such as the brain. Dysregulation and transcriptional activation of TEs has been implicated in the etiology of several neurological disorders.
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