May
LUBI seminar series - Jacob Vogel: Human multi-omics from brain organization to neurodegenerative disease
Description:
I am an Associate Senior Lecturer at the Department of Clinical Sciences, and a fellow of the SciLifeLab and Wallenberg National Program for Data-driven Life Science. My lab. My lab’s research uses AI, informatics and multi-modal neuroimaging and multi-omics data to characterize the onset and spread of neurodegenerative pathology, and to model how the human brain changes in response to it.
In this talk, I will discuss examples of how multi-omic data can be combined with mesoscale neuroimaging data to learn more about brain organization and the progression of neurodegenerative disease. In the first half of the talk, I will present work using spatially-resolved whole-brain transcriptomics to investigate how the spatial distribution of gene expression informs functional differentiation in the adult human brain. In the second half of the talk, I will discuss recent efforts from our group to profile the cerebrospinal fluid proteome of patients with Alzheimer’s disease and neurovascular disease. Together, these studies highlight how emerging data is advancing our collective ability to derive biological insight directly from human clinical data.
Register here
Fika is included.
About the event
Location:
Segerfalkssalen
Contact:
karin [dot] engstrom [at] med [dot] lu [dot] se